Clinicians should ensure that reported laboratory results for ALP reflect age- and sex-adjusted reference ranges for the specific patient.

Check with your lab for their appropriate age- and sex-adjusted reference range.

This resource is for educational purposes only. It is not intended for use in diagnosis of any disease or condition or for the cure, mitigation, or treatment of any disease or condition. It does not replace a healthcare professional’s judgment or clinical diagnosis.
Connect the HPP dots with this tool that helps recognize suspect patients warranting further clinical evaluation.
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Adeli K, Higgins V, Nieuwesteeg M, et al. Clin Chem. 2015;61(8):1049-1062. Quest Diagnostics. Accessed April 21, 2026. https://testdirectory.questdiagnostics.com/test/test-detail/234/alkaline-phosphatase?p=r&q=Alkaline%20Phosphatase&cc=MASTER Labcorp. Accessed April 21, 2026. https://www.labcorp.com/tests/001107/alkaline-phosphatase ARUP Laboratories. Accessed April 21, 2026. https://ltd.aruplab.com/Tests/Pub/0021020 Colantonio DA, Kyriakopoulou L, Chan MK, et al. Clin Chem. 2012;58(5):854-868. Kishnani PS, Seefried L, Ozono K, et al. Orphanet J Rare Dis. 2025;20(1):626. Rush E, Brandi ML, Khan A, et al. Osteoporos Int. 2024;35(1):1-10. Brandi ML, Khan AA, Rush ET, et al. Osteoporos Int. 2024;35(3):439-449. Vieira LHR, Peixoto KC, Flósi CL, et al. Arch Endocrinol Metab. 2021;65(3):289-294.