Premature loss of baby teeth with root intact, 2 nontraumatic fractures in his teenage years, kidney stone 2 years ago, ALP value reported as 30 U/L* on lab results 2 years ago.
Persistently low ALP can differentiate HPP from other metabolic disorders with overlapping symptoms.
HPP is a heterogenous disease. Patients may present with symptoms that affect one or more areas of the body:1-4
Patient image is hypothetical.
References: 1. Bianchi ML, et al. Osteoporos Int. 2020;31(8):1445-1460. doi: 10.1007/s00198-020-05345-9. 2. Mornet E. Hypophosphatasia. In: Adam MP, Ardinger HH, Pagon RA, et al, eds. GeneReviews®. University of Washington; 2007. Accessed November 4, 2021. https://www.ncbi.nlm.nih.gov/books/NBK1150/ 3. McKiernan FE, et al. J Bone and Miner Res. 2014;29(7):1651-1660. doi: 10.1002/jbmr.2178 4. Rockman-Greenberg C. Pediatr Endocrinol Rev. 2013;10(suppl 2):380-388.