Image is not of an actual patient.
Hypophosphatasia (HPP) may feel
different for every patient, but it should
never feel unimportant
See how symptoms may impact your patient’s ability to work, connect, learn, and live independently1-5
HPP and Low ALP
Multisystemic Symptoms 
LIFE IMPACT
Diagnosing HPP

[HPP's] not, at least for me, it's not any one thing, it's a whole bunch of things all at once.

— Patient, living with HPP

 Weber TJ, Sawyer EK, Moseley S, Odrljin T, Kishnani PS. Metabolism. 2016;65(10):1522-1530. Pierpont EI, Simmons JH, Spurlock KJ, Shanley R, Sarafoglou KM. Orphanet J Rare Dis. 2021;16(1):80. Durrough C, Colazo JM, Simmons J, et al. Bone. 2021;142:115695. Dahir KM, Seefried L, Kishnani PS, et al. Orphanet J Rare Dis. 2022;17(1):277. Högler W, Langman C, Gomes da Silva H, et al. BMC Musculoskelet Disord. 2019;20(1):80. Villa-Suárez JM, García-Fontana C, Andújar-Vera F, et al. Int J Mol Sci. 2021;22(9):4303. Conti F, Ciullini L, Pugliese G. Clin Cases Miner Bone Metab. 2017;14(2):230-234.