Legal

Alexion Pharmaceuticals, Inc. and its affiliated companies (together, “Alexion”, “we”, or “the Company”) provide this website as a source of general information about the Company. This website is linked to other websites and applications for mobile devices (“Applications”) provided by Alexion, which together with this website shall be referred to in this statement as the “Alexion Sites” or “Sites.”

PLEASE READ THIS LEGAL STATEMENT CAREFULLY BEFORE USING THE SITES. THIS STATEMENT INCLUDES:

TERMS OF USE
PRIVACY STATEMENT

BY USING THE SITES, YOU SIGNIFY YOUR ASSENT TO THESE TERMS. IF YOU DO NOT AGREE TO THESE TERMS, PLEASE DO NOT USE THE SITES.

Alexion has made reasonable efforts to ensure that information is complete and accurate when posted. However, Alexion makes no warranties or representations as to the completeness or accuracy of the information presented. Further, Alexion does not undertake any obligation to update any information that may change after posting. The medical information contained on the Sites is intended for informational purposes only. It is not a substitute for actual medical care. Persons requiring diagnosis or treatment or with questions specific to a single individual are urged to contact their local healthcare provider.

Case Study:
Identifying and Diagnosing HPP.

Case Study: Identifying and Diagnosing HPP.

This is Nathan

A 52-year-old man referred to an endocrinologist for fatigue and pain.

Hypothetical patient case.

History of presenting illness

Bone pain in his back and thighs
Chronic fatigue, which negatively impacts his work as a high school teacher
Pain has been ongoing for years, but he was dismissive of symptoms because several family members reported similar experiences

Medical History

Premature loss of baby teeth with root intact, 2 nontraumatic fractures in his teenage years, kidney stone 2 years ago, ALP value reported as 30 U/L* on lab results 2 years ago.

Social History

High school teacher for the past 25 years, denies tobacco or alcohol use.

Family history

Osteoporosis (mother); hypertension (father, myocardial infarction at 67).

Medications

Over-the-counter medication twice daily for pain, calcium and vitamin D supplement once daily.

Lab results show low ALP but it is not noted as a concern by the physician

(H) = high, (L) = low.

*Age- and sex-adjusted normal range for adults, >20 years and older, 40-120 U/L.^1-5

Check with your lab for their appropriate age and sex-adjusted reference range.

References: 1. Adeli K, et al. Clin Chem. 2015;61(8):1049-1062. doi: 10.1373/clinchem.2015.240515 2. Schumann G, et al. Clin Chem Lab Med. 2011;49(9):1439-1446. doi: 10.1515/CCLM.2011.621 3. Quest Diagnostics. Alkaline phosphatase. Accessed July 28, 2021. https://testdirectory.questdiagnostics.com/test/test-detail/234/alkaline-phosphatase? cc=MASTER 4. Labcorp. Alkaline phosphatase. Accessed July 28, 2021. https://www.labcorp.com/tests/001107/alkaline-phosphatase# 5. ARUP Laboratories. Alkaline phosphatase isoenzymes, serum or plasma. Accessed July 28, 2021. https://ltd.aruplab.com/Tests/Pub/0021020

Case Study:
Identifying and Diagnosing HPP.

Case Study: Identifying and Diagnosing HPP